of Invention Capital Associates, co-wrote: “The power of CRISPR is extraordinary: it has already been used to reverse muscular dystrophy in living mammals and as a live edit- ing tool for our genome, it has the potential to be the most powerful discovery in history.” As far as the seed industry goes, Pioneer (turned DowDuPont, turned Corteva Agriscience) had the foresight to corral licenses to the intellectual property from both the UC-Berkeley and the Broad teams. The company is now the single biggest owner of CRISPR patents and applications glob- ally with 514, or 12 per cent of the total. The company uses CRISPR to develop corn and soybean crops that repel insects without chemical pesti- cides and that tolerate herbicides for easier control. According to a Bloomberg article, since the end of 2016, about 100 new inventions are being disclosed every month. “The market concerns I have heard is that the CRISPR patent landscape is very large, very confus- ing and difficult to navigate,” says Kristin Neuman, executive director for Biotechnology Licensing at MPEG LA, a group that’s trying to develop a patent pool. Neuman says it’s hard for people to figure out what rights they need to license and who they need to license. This patent pool would serve as a one-stop shop for anyone wanting to license the basic technology, no matter which enzyme variant is used. Billions of dollars in licensing agreements are at stake. Either way the court goes, the companies licens- ing from the losing party will have to Delivery - Exosome Delivery - Liposomes Delivery - Microvesicle Delivery - Nanoparticle Mediator - Cas9 Mediator - Cpf1 Mediator - gRNA Mediator - PAM Mediator - TracrRNA Use - Diagnosis Use - Gene Editing Use - Gene Therapy Use - Formulation Use - Regulating Use - Targeting Vector - Bacterial Vector - Plasmid Vector - Viral 46 Inventions 125 25 168 1156 82 959 190 278 1010 161 147 250 131 222 452 579 19 CRISPR TECHNICAL APPROACHES seek new license agreements from the party that prevails. This could impact company stocks and time to market with products in development.